Video Drivers
If the game crashes on startup or during scene transitions, it may be due to outdated video drivers. Please try updating your video card drivers to the latest version.
Steam
If you've purchased the game on Steam, verify the integrity of your game files using the procedure detailed here:
https://support.steampowered.com/kb_article.php?ref=2037-QEUH-3335
Once that's done, relaunch the game and try again.